Objectives: From the psychological point of view, coping strategies and ATTITUDES have considerable effects on people’s tendency towards risky behavior, including opioid substance abuse. DYSFUNCTIONAL ATTITUDES are ATTITUDES and beliefs that predispose the individual toward depression and psychological disorder, generally speaking. Usually, people use three types of coping strategies when confronting stressful situations; problem-focused, emotion-focused and avoidance strategies. This study therefore aimed to compare DYSFUNCTIONAL ATTITUDES and coping strategies in substance-dependent & healthy individuals.Methods: A causal-comparative study was conducted. The population under study consisted of 100 addicts attending Robat-Karim’s addiction rehabilitation centers who were selected through simple random sampling. Another 100 ordinary individuals were matched with the addicts. The DYSFUNCTIONAL ATTITUDES scale and the coping strategies questionnaire was used to collect data. Multivariate analysis of variance was used to analyze data.Results: The two groups differed significantly in their DYSFUNCTIONAL ATTITUDES and problem-focused and emotion-focused coping strategies. Substance-dependent individuals applied emotion-focused coping more and had greater DYSFUNCTIONAL ATTITUDES than the healthy ones, and the latter applied problem-focused strategies more.Discussion: Based on our results, addicts have greater DYSFUNCTIONAL ATTITUDES than non-addicts. Therefore, better treatment and rehabilitation results may be obtained by preparing grounds for appropriate psychological interventions and coping strategies in substance-dependent individuals.